Design, Synthesis, Anti-HIV Activity and Cytotoxicity of Novel Schiff’s base of Indeno[1,2-b]quinoxalin-11-one Derivatives

A series of novel 11-Indeno[1,2-b]quinoxalin-11-one have been synthesized by condensation of Indeno[1,2-b]quinoxalin-11-one and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR, H-NMR). Synthesized compounds were screened for in vitro antiviral activity against HIV -1 and -2 in MT-4 cells and Cytotoxicity was also investigated in mock-infected MT-4 cells by using MTT assay. All the compounds exhibits cytotoxicity in MT-4 cellsand compound IDME-2ABT exhibited a distinct antiviral activity against HIV-2 (IC50: 2.55±0.23 μg/ml and CC50: 11.16±2.90 μg/ml, SI=4) in MT-4 cells.